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This milestone can be reached in as early as 3 months and as late as 5 months depending on the number of miles you run weekly (20 miles or more). If you're on the heavier side, you should replace them every 300 miles to Ensure your safety leptitox nutrition and comfort when you're running. Remember, they may still look good but that doesn't mean they have not worn down on the inside. 3. WARM UP BEFORE YOU RUN Warming up before you run is good for your..